In the Lab:
Menu Accuracy Reporting as well as the examination of; Natural Toxins, Botulinum Neurotoxin, Clostridum Botulinum, Foodborne Pathogens, Genetics and biochemistry of botulinum toxin, the isolation, and characterization of antimicrobial compounds from natural sources, and the biosynthesis of carotenoid pigments in yeasts found in unusual ecological niches.
Troubleshooting:
- Interspecies transfer of the gene coding for botulinum toxins.
- Regulation of expression of botulinum toxins.
- Purification, stabilization, and characterization of botulinum toxins.
- Development of botulinum toxin as a pharmaceutical.
- Behavior and control of Clostridium botulinum in foods.
- Assessment of the safety of new food processing procedures, e.g., modified atmosphere packaging, on safety from botulism.
- Characterization and application in foods of naturally occurring antimicrobials, including lactoperoxidase, lactoferrin, monoglycerides, polyacetylenes, lysozyme, and other lytic enzymes.
- Behavior and control of Listeria monocytogenes in foods.
- Control of pathogens in reduced fat cheeses.
Patents:
Years of research has proven out in many breakthrough patents.
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| P Number | Title | Country Name | Status | Filing Date | Serial Number | Publication Date | Publication Number | Issue Date | Patent Number |
| P00282US | METHOD OF TARGETING PHARMACEUTICALS TO MOTOR NEURONS | UNITED STATES | ISSUED | 5/30/2001 | 09/870262 | 8/7/2003 | US-2003-0147921 | 12/30/2003 | 6670322 |
| P01121US | HYBRID BOTULINAL NEUROTOXINS | UNITED STATES | ISSUED | 11/3/2000 | 09/706047 | 9/3/2002 | 6444209 | ||
| P02398US | PNA PROBES, PROBE SETS, METHODS AND KITS PERTAINING TO THE DETERMINATION OF LISTERIA | UNITED STATES | FILED | 5/13/2002 | 10/436962 | ||||
| P04467US | METHOD OF PREPARING BOTULINUM NEUROTOXIN TYPE A LIGHT CHAIN | UNITED STATES | ISSUED | 4/14/2006 | 11/404289 | 11/16/2006 | 12/16/2008 | 7465457 | |
| P05066US | PHARMACEUTICAL COMPOSITION CONTAINING BOTULINUM B COMPLEX | UNITED STATES | ISSUED | 10/3/1994 | 08/316820 | 12/9/1997 | 5696077 | ||
| P06126US | DEVICE AND METHODS FOR LIQUID CRYSTAL-BASED BIOAGENT DETECTION | UNITED STATES | ISSUED | 10/31/2006 | 11/555103 | 10/4/2007 | US-2007-0231832 | 3/22/2011 | 7910382 |
| P06126US02 | DEVICE AND METHODS FOR LIQUID CRYSTAL-BASED BIOAGENT DETECTION | UNITED STATES | FILED | 1/21/2011 | 13/011514 | 7/28/2011 | US-2011-0183357 | ||
| P06269US | PLASMIC-ENCODED NEUROTOXIN GENES IN CLOSTRIDIUM BOTULINUM SEROTYPE A SUBTYPES | UNITED STATES | FILED | 6/29/2007 | 12/664800 | 12/9/2010 | US-2010-0311118 | ||
| P07412US | METHOD OF DETECTING BOTULINUM NEUROTOXIN AND ANTIBODIES THAT NEUTRALIZE BOTULINUM NEUROTOXIN ACTION | UNITED STATES | FILED | 11/10/2008 | 12/291411 | ||||
| P08309US | ESCHERICHIA COLI-DERIVED VACCINE AND THERAPY AGAINST BOTULISM | UNITED STATES | ISSUED | 2/29/2008 | 12/040542 | 1/15/2009 | US-2009-0017495 | 10/26/2010 | 7820411 |
| P09050US02 | A NOVEL SUBTYPE OF CLOSTERIDIUM BOTULINUM NEUROTOXIN TYPE A AND USE THEREOF | UNITED STATES | FILED | 4/29/2010 | 12/769754 | 7/14/2011 | US-2011-0171226 | ||
| P09079US02 | NONTOXIGENIC CLOSTRIDIUM BOTULINUM STRAINS AND USES THEREOF | UNITED STATES | FILED | 8/31/2009 | 12/550692 | 5/6/2010 | US-2010-0112149 | ||
| P09171US | METHOD OF PREPARING BOTULINUM NEUROTOXIN TYPE E LIGHT CHAIN | UNITED STATES | ISSUED | 11/18/2008 | 12/273157 | 7/16/2009 | US-2009-0182123 | 11/16/2010 | 7833524 |
| P100091US02 | CONJUGATIVE PLASMIDS AND METHODS OF USE THEREOF | UNITED STATES | FILED | 10/15/2010 | 12/905592 | 7/14/2011 | US-2011-0171734 | ||
| P110348US01 | PURIFICATION, CHARACTERIZATION AND USE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN BoNT/A3 | UNITED STATES | FILED | 9/28/2011 | 61/540321 | ||||
| P94051US | PHARMACEUTICAL COMPOSITION OF BOTULINUM NEUROTOXIN AND METHOD OF PREPARATION | UNITED STATES | ISSUED | 10/13/1994 | 08/322624 | 4/30/1996 | 5512547 | ||
| P95168US | HYBRID BOTULINAL NEUROTOXINS | UNITED STATES | ISSUED | 10/28/1996 | 08/739477 | 8/17/1999 | 5939070 | ||
| P95242US | PHARMACEUTICAL COMPOSITIONS OF BOTULINUM TOXIN OR BOTULINUM NEUROTOXIN AND METHODS OF PREPARATION | UNITED STATES | ISSUED | 3/27/1996 | 08/624771 | 5/26/1998 | 5756468 | ||
| P96019US | PURIFICATION OF TYPE G BOTULINUM NEUROTOXIN AND PHARMACEUTICAL COMPOSITIONS THEREOF | UNITED STATES | ISSUED | 4/16/1996 | 08/633092 | 12/8/1998 | 5846929 | ||
| P97017US | CHIMERIC TOXINS | UNITED STATES | ISSUED | 3/14/2000 | 09/524841 | 4/8/2003 | 6545126 | ||
| P97137US | METHOD OF SENSITIZING MICROBIAL CELLS TO ANTIMICROBIAL COMPOUNDS | UNITED STATES | ISSUED | 6/22/1998 | 09/102466 | 11/20/2001 | 6319958 | ||
| P98171US | EXPRESSION SYSTEM FOR CLOSTRIDIUM SPECIES | UNITED STATES | ISSUED | 4/6/1998 | 09/056075 | 9/21/1999 | 5955368 | ||
| P100091WO01 | CONJUGATIVE PLASMIDS AND METHODS OF USE THEREOF | W.I.P.O. (IS PCT) | FILED | 10/15/2010 | PCT/US2010/052863 | 4/21/2011 | WO2011/047274 | ||
| P06269AU01 | PLASMID-ENCODED NEUROTOXIN GENES IN CLOSTRIDIUM BOTULINUM SEROTYPE A SUBTYPES | AUSTRALIA | FILED | 6/27/2008 | 2008270020 | ||||
| P05066CA | PHARMACEUTICAL COMPOSITION CONTAINING BOTULINUM B COMPLEX | CANADA | ISSUED | 6/22/1993 | 2/16/1999 | 2138020 | |||
| P06269CA01 | NOVEL BOTULINUM NEUROTOXIN TYPE A SUBTYPES FOR PHARMACEUTICAL USE | CANADA | FILED | 6/27/2008 | 2691825 | ||||
| P09050CA01 | A NOVEL SUBTYPE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE A AND USE THEROF | CANADA | FILE OPENED | 4/30/2010 | |||||
| P95242CA | PHARMACEUTICAL COMPOSITIONS OF BOTULINUM TOXIN OR BOTULINUM NEUROTOXIN AND METHODS OF PREPARATION | CANADA | ISSUED | 9/16/1996 | 2250251 | 11/6/2001 | 2250251 | ||
| P06269EP01 | NOVEL BOTULINUM NEUROTOXIN TYPE A SUBTYPES FOR PHARMACEUTICAL USE | EUROPEAN PATENT OFFICE | FILED | 6/27/2008 | 08772138.7 | 3/31/2010 | 2167532 | ||
| P09050EP01 | A NOVEL SUBTYPE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE A AND USE THEROF | EUROPEAN PATENT OFFICE | FILED | 4/30/2010 | 10718786.6 | ||||
| P95242FR | PHARMACEUTICAL COMPOSITIONS OF BOTULINUM TOXIN OR BOTULINUM NEUROTOXIN AND METHODS OF PREPARATION | FRANCE | ISSUED | 9/16/1996 | 96933019.0 | 12/12/2001 | 0889730 | ||
| P95242DE | PHARMACEUTICAL COMPOSITIONS OF BOTULINUM TOXIN OR BOTULINUM NEUROTOXIN AND METHODS OF PREPARATION | GERMANY | ISSUED | 9/16/1996 | 96933019.0 | 12/12/2001 | P69618018.9 | ||
| P95242GB | PHARMACEUTICAL COMPOSITIONS OF BOTULINUM TOXIN OR BOTULINUM NEUROTOXIN AND METHODS OF PREPARATION | GREAT BRITAIN | ISSUED | 9/16/1996 | 96933019.0 | 12/12/2001 | 0889730 | ||
| P95242IE | PHARMACEUTICAL COMPOSITIONS OF BOTULINUM TOXIN OR BOTULINUM NEUROTOXIN AND METHODS OF PREPARATION | IRELAND | ISSUED | 9/16/1996 | 96933019.0 | 12/12/2001 | 0889730 | ||
| P05066JP | PHARMACEUTICAL COMPOSITION CONTAINING BOTULINUM B COMPLEX | JAPAN | FILED | 6/22/1993 | 06-502542 | ||||
| P95242JP | PHARMACEUTICAL COMPOSITIONS OF BOTULINUM TOXIN OR BOTULINUM NEUROTOXIN AND METHODS OF PREPARATION | JAPAN | ISSUED | 9/16/1996 | 09-534359 | 1/8/2003 | 11/1/2002 | 3364658 | |
| P06269NZ01 | NOVEL BOTULINUM NEUROTOXIN TYPE A SUBTYPES FOR PHARMACEUTICAL USE | NEW ZEALAND | FILED | 6/27/2008 | 582087 |